BC FOR LATER READ
Saved by @CodyyyGardner

*puts on hard hat, respirator, asbestos gloves* (hey i haven't used these in awhile!)

okay. i'm seeing the same claims on my TL over & over that quite frankly, make no sense. & now they're starting to broken-telephone into each other so:

my thoughts on vaccine schedule.

 first off, let me get one thing across to start: this is not 2 doses v. 1 dose, it's 2 spaced 3-4 weeks apart vs. 2 spaced several months apart.
anyway, to begin: if you are reluctant to modify vaccine dosing schedule from the 3-weeks-apart one that we had in the Pfizer/BioNTech PhaseIII, *that's fine*. that's a legitimate reason.

but say just that. we know this works, we don't know about other regimes.
but for the love of all that is holy, please do not try to imply that this is a hard requirement, or optimal (imho, it likely isn't), or even *chosen for any reason other than being the shortest interval we could use to complete the PhIII ASAP*. that's it.
i'll be honest, i'm amazed 3 weeks *works*. it's shorter than *the shortest MINIMUM interval* for any other vaccine as scheduled according to, say, the CDC: https://t.co/rdb6TIHWPl
like, the whole point of a boost dose in a prime-boost vaccine schedule is to generate a *secondary* immune response.

primary seroconversion takes about 2 weeks (that's why the attack rate in the trials was still high then, then fell off a cliff).
three weeks in you've barely formed proper germinal centers, you quite likely will still hit the primary response quite often then.

as an aside, a few things that i keep hearing that further make no sense:
the "95% efficacy" or "70% efficacy" figure is a *population* efficacy figure.

it means that if 100 of you sign up for Tai-Tai's Cluster Dancing Lessons (so fresh you're guaranteed to go viral!), only 5 (or 30) of you will contract #COVIDー19 after attending.
it does *not* mean that *you yourself* have a 5% of contracting it, be it per exposure, or overall, or whatnot. there is no "partial immunity". you either seroconvert or you don't.

none of this is new, we've studied this extensively for MMR: https://t.co/zRf61T1qcO
we give a booster there (after *five years* typically!) not b/c one dose is "85% effective" for someone, it's b/c only about 85% of people seroconvert after one dose, & 97%+ after two.
fortunately we can easily check this for #COVIDー19 w/a Spike ELISA after 3 weeks. negative? boost then. otherwise...

i stand by this claim, even more strongly than before: https://t.co/5YlJNPGmLO
while i wasn't expecting this to happen this early or this catastrophically, *IT WAS GOING TO HAPPEN*.

we can yell at each other over what is optimal until we are blue in the face & we all hate each other for no reason, or...
...we can accept that we are in an out-of-control pandemic where there is, on average right now one person dying of #COVIDー19 somewhere in this world every *seven seconds*, realize that delaying doses is fundamentally not immunologically unsound, and therefore...
look, i get that clinical trials are hard. i really do. trust me on this. & i get that it's important to prioritize ones that are likely to produce results that are vitally important right now.
but i'd say when random world gov'ts are trying this sort of stuff w/o a trial, b/c the situation is so dire *the entire medical system is about to collapse in London right now*, your hand is a bit forced.

to say nothing of countries that can only afford 1 dose/person this year.
because guess what? immunologically it makes sense that it would work. in fact, it stands to reason (& it's interesting comparing the immunologists/vaccinologists on my TL to the virologists) that it will work *better*.
and if everyone's fears are realized & it doesn't? well here's some nice hard data to stop anyone else from trying this, from very early on in the world vaccination schedule, that's a heck of a lot more convincing if you need to stop someone like BoJo.
a few final asides: if you seroconvert & class-switch to IgG that means you've had a T_{FH}/B-cell germinal center response, which means that yes, you have developed memory B cells to that antigen. which survive decades.
i don't understand why i still keep hearing the whole "immunity fading" argument (and after TWELVE WEEKS?!? please show me an example of that in the literature, i tried really hard to find that the past two days w/no success).
i thought after @jbloom_lab demonstrated that reinfection to HCoVs was due to *antigenic drift* & not like when CoV-specific memory B cells inexplicably decide to take a vacation that year, i'd stop hearing that repeated so often...
...particularly when it does not work this way for any other of our vaccines that are currently on the market.

some references: https://t.co/muK3HQdgJ6 / https://t.co/muK3HQdgJ6 / https://t.co/4K4Bafimvm / https://t.co/RdckhYyksv / https://t.co/bV2We9NFN8
https://t.co/BNr7KXTiOS / https://t.co/jYownNFueX / https://t.co/CrNreAMbdl / https://t.co/25XdiivC5g

More from For later read

David Boxenhorn
David Boxenhorn
@davidboxenhorn
1. The death of Silicon Valley, a thread

How did Silicon Valley die? It was killed by the internet. I will explain.

Yesterday, my friend IRL asked me "Where are good old days when techies were


2. In the "good old days" Silicon Valley was about understanding technology. Silicon, to be precise. These were people who had to understand quantum mechanics, who had to build the near-miraculous devices that we now take for granted, and they had to work

3. Now, I love libertarians, and I share much of their political philosophy. But you have to be socially naive to believe that it has a chance in a real society. In those days, Silicon Valley was not a real society. It was populated by people who understood quantum mechanics

4. Then came the microcomputer revolution. It was created by people who understood how to build computers. One borderline case was Steve Jobs. People claimed that Jobs was surrounded by a "reality distortion field" - that's how good he was at understanding people, not things

5. Still, the heroes of Silicon Valley were the engineers. The people who knew how to build things. Steve Jobs, for all his understanding of people, also had quite a good understanding of technology. He had a libertarian vibe, and so did Silicon Valley
FOR LATER READ
Simon Wardley
Simon Wardley
@swardley
X : Do you think cloud will decentralise?
Me : Already has - started with regions and AZs and is now rapidly expanding into outpost, greengrass, EKS anwhere.
X : No, I mean many providers.
Me : There are two forms of decentralisation - provision and control (i.e. authorities) ...

... what is happening is decentralisation of provision (i.e. cloud everywhere, at the edge) but under centralised authorities (Amazon, Alibaba, MSFT, Google etc).
X : What about decentralisation of control?
Me : Many companies working to a common standard ...

... that was the dream of OpenStack but they blew that on day one creating a collective prisoner dilemma. They are trying to recorrect this with K8s but the cloud has moved on, higher up the stack ...

... so, the idea of a marketplace of many different companies each having authority is ... wishful thinking by past vendors and clients they've hoodwinked. Maybe in 15-20 years we will get another go ... open source is a long game ...

... more likely is many points of provision i.e. companies offering EKS anywhere on a utility basis but under centralised authority e.g. AWS.

So, yes, the cloud is going to edge, has been for sometime but it'll be AWS / Alibaba / MSFT cloud that is everywhere.
FOR LATER READ
Advertisement
NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
2020 marks the start of the quantum dot revolution.

Completely ignoring the fact that "photocatalytic generation of reactive oxygen species (ROS) from quantum dots (QDs) has been widely reported."

Results: It was found that whereas singlet oxygen (1O2) was not produced by photoexcited QDs, superoxide anion(O2− )and hydroxyl radicals(OH) were generated by QDs, especially in the presence of a physiological concentration of electron donating agent including NADH.

Using cell metabolic activity assays and various probes of ROS generation, the formation of ROS in cellular environments was demonstrated.

Conclusion: Illumination of QD-treated cells and bacteria with light did affect viability. The above results, together with those of assays in the presence of various scavengers of specific ROS, indicate that the formation of ROS by QDs mainly proceeded via electron transfer.
FOR LATER READ
JesseJenkins
JesseJenkins
@JesseJenkins
Morning. The #TexasFreeze continues & grid operator ERCOT is still reporting >31,000 MW of thermal generation capacity out as of 9AM CT. Down slightly from a peak of 34,000 MW reported yesterday afternoon (https://t.co/jNMR4ibyY0) but still >40% of thermal capacity in state!


Wind power is currently producing about 4,000 MW, or 2/3 of the ~6,000 MW that ERCOT was counting on wind to contribute during winter peaking events. Solar is coming online now and helping during daytime, exceeding the <300 MW it is counted on for in system planning.


Main story continues to be the failure of thermal power plants -- natural gas, coal, and nuclear plants -- which ERCOT counts on to be there when needed. They've failed. Of about 70,000 MW of thermal plants in ERCOT, ~25-30,000 MW have been out since Sunday night. Huge problem.

ERCOT started directing electric utilities (like Oncor or Austin Electic) to start rolling blackouts or involuntary emergency load shedding at 1:25am on Monday morning, with 10,500 MW shed during that late morning. That's ~2 million homes worth of load

Throughout Monday, many thermal power plants remained offline, as freeze-offs + fuel shortages in gas pipelines forced large numbers of natural gas plants offline. Many coal plants likely struggled as well w/frozen coal piles, but breakdown of thermal outages by fuel type unclear
FOR LATER READ
MALUME ZANO
MALUME ZANO
@ZanoUrban
(PART 3) Angels - Izingelosi | Izithunywa of the 1st Sphere 🕯

[A Smallanyana Thread]

On Part 1 and 2, you will notice that we covered Angels that somehow also resemble human physical/ manifested features.

Part of the classic examples of how we as humans always depict these Celestial Beings through our works of art.

As we move up to the 1st Sphere of the Christian Angelology Hierarchy we get introduced to another breed of Izithunywa.

Let's Begin 📖

THRONES:

Also known as the Elders, they are a class of Celestial Beings mentioned by Paul the Apostle in Colossians 1:16, and they are also mentioned in the Book of Revelations as the 24 Elders.

They are the living symbols of God's justice and authority, symbolised as Thrones.

They are also associated with the Ophanim from the Jewish Angelic Hierarchy (Which we will still cover in detail within this series of Threads).

The Ophanim are referenced as Wheels seen in Ezekiel's vision of the Chariot in Ezekiel 1:15 - 21.

Also refer to Elijah's ascension.
FOR LATER READ

You May Also Like

Aditya Todmal
Aditya Todmal
@AdityaTodmal
Boss is always Boss @Mitesh_Engr

Mitesh Sir's FUTURES BREAKOUT TRADES 101:

• How to pick stocks at right time?
• What to look for?
• Importance of BO post consolidation
• How to manage SL
• How to get huge profits
• Multiple Examples

In collaboration with @niki_poojary


Importance of Trading only BO or BD stocks by @Mitesh_Engr Sir: 👇

•Two questions to always ask:

~Why stock is going up/down and when?
~ Who is behind big up/down and when?

• Trade only stocks with Momentum
• Instant results
• Small SL or huge profits


Sir's take on how to Trade: 👇

• Observe fight between buyer & seller
• Position will be created within first 3 hours
• Operators will win
• Just find BO or BD
• Look for huge volume support
• Give company to operators
• ATP importance explained


How to take trade in Breakout/Breakdown stocks by @Mitesh_Engr Sir: 👇

• Check Support & Resistance
• Wait for 2-3 months consolidation
• Surge in volumes
• Trade on 3 min charts
• Small SL
• Keep trailing
• Always pyramid in profit


When and Why to Pyramid? By @Mitesh_Engr Sir

• Adding to winning positions
• Signals of continued strength
• Potentially large profits
• An Example of pyramiding in one of his trades
MPLEARNINGS , ALL , MPTRADERULES
Kitze @ \U0001f1e9\U0001f1ea\ufe0f
Kitze @ 🇩🇪️...
@thekitze
To people who are under the impression that you can get rich quickly by working on an app, here are the stats for https://t.co/az8F12pf02

📈 ~12000 vistis
☑️ 109 transactions
💰 353€ profit (285 after tax)

I have spent 1.5 months on this app. You can make more $ in 2 days.

🤷‍♂️


I'm still happy that I launched a paid app bcs it involved extra work:

- backend for processing payments (+ permissions, webhooks, etc)
- integration with payment processor
- UI for license activation in Electron
- machine activation limit
- autoupdates
- mailgun emails

etc.

These things seemed super scary at first. I always thought it was way too much work and something would break. But I'm glad I persisted. So far the only problem I have is that mailgun is not delivering the license keys to certain domains like https://t.co/6Bqn0FUYXo etc. 👌

omg I just realized that me . com is an Apple domain, of course something wouldn't work with these dicks
MAKERS
Advertisement
Dr Catherine Pemble is #SocialDistancing
Dr Catherine Pemble is...
@CatherinePemble
Right, screw it. Here's a thread on *that* FBLive by Alex Cairnie about #Govanhill. Lets do a watch-through shall we? (Mind, I'm a resident of Govanhill, and a sociologist. I'm also 5'3, and a visibly queer woman so if half his claims are true I should be living in terror)

00:30: Welcomes viewers and uses points out that his videos are only getting attention b/c they're 'horrific'. Directs folk to his Youtube page. So already clout hunting.

1:08: "I've been warned to stay out of Govanhill. I'm a marked man" (proceeds to use a beanie as a disguise)

1:30 "Laughing and joking aside, here's somebodys front garden." Proceeds to show litter and claim its thrown from windows and this is 'common'. I know a handful of streets with litter issues like this, but its neither common nor unique to #govanhill and other deprived areas.

2:10 "Don't be under any illusion I'm only showing you the bad bits" - only shows you the bad bits.

3:45: He's had offers of help, but hes said no because hes not responsible for 'anybody elses safety' Good lord.

5:01: "Its not that bad. But its not all good either" -Correct

6:00: TW: child abuse - He starts claiming to have been contacted by a health professional and told about child abuse 'in the area'. Huge ethical issues here as the 'professional' who has 'been in the game a long time' is reporting to Facebook Dude and not authorities.
HEALTH
Akshaya Sivaraman
Akshaya Sivaraman
@AksUnik
How did I go from a busily scheduled life to one with substantial unstructured time?

1/ More creating, less consuming

I stopped obsessive mindless scrolling and started creating. Instagram for artworks. Twitter for thoughts. Unsubscribed from other apps. Saved a LOT of time.

2/ More deep focus, less context switching

I loved to be involved in many projects, but didn’t take into account the cost of making the mind switch between works. I decided to choose one important project and pour all of me into it.

3/ “It’s either hell yeah, or no”

I dropped projects that didn’t make me feel all fervent. I ruthlessly purged the guilt and FOMO. It was hella scary and uncomfortable at first, but was liberating over time. Knowing your why is the key.

4/ More focus on health and people

I was generous with time when it was for my health and people. I exercised, did yoga, went on for walks, and slept whenever I wanted. Same way, I didn’t look at the clock when I was with people. I resolved to be there and only there.

5/ Less worrying about saying no

Well, this was perhaps the toughest one for me. I was so used to being involved in many projects, that retracting myself from them was almost impossible. It was SO painful. Yet, I trusted it would be a wise choice long term and bore the pain.
ALL
Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)

@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice


@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2


@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj


@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
ALL