I've worked on a mAb and i will happily admit i didn't get the details! 1/
@PaoloWalnuts I looked into this as I was very surprised and thought it could be quite dangerous to go against the trial design.
I learnt a lot while i was doing it! There are a lot of misunderstandings and quite a few counterintuitive bits as well.
Thread...
I've worked on a mAb and i will happily admit i didn't get the details! 1/
I know how limited pfizer are in what they can claim. If they don't have data to prove something they can't claim it, even if it *really* is obvious. They have data on 21 days so they either stay quiet or they say the data support 21dy interval. 5/
So, why choose 21 days? 7/
21 days should long enough to work but quick enough to get data 9/
I'll try to hunt out the threads i came across. 10/
I also think it's been poorly communicated though. I understand why - in many ways JVCI, SAGE, MHRA et al have a lot to worry about right now! 12/
Clearly, in this case, giving everybody 1 dose will provide much more protecting and save very many lives.
*I'm coming on to this... 14/
15/
The numbers are skewed by all the pts who were infected before they were given the vx, or in the 7-14 days after it was administered. The fact that those folks get covid doesn't tell us how effective the vx is (just how long it takes to start working). So? 16/
We don't need to worry about the vaccine being effective after 1 dose. It is, stunningly so. 17/
https://t.co/5nw32LPiEk
What it suggests to me is that the projections for January and February must be properly frightening.
— Chris McQuillan (@ChrisMcQuilla13) January 1, 2021
https://t.co/WkD6pFZVbz
@Sandyddouglas
This issue is, appropriately, contentious. As a vaccinologist - & citizen & relative of people in at-risk groups - I fully support the UK decision to increase dose intervals of both our Ox/AZ product and the Pfizer product. I'd happily receive either with a >8w gap. Here's why \U0001f9f5 https://t.co/PZaxgGJUj4
— Sandy Douglas (@sandyddouglas) January 1, 2021
https://t.co/U3OEnGOrpw
Like me, \u2066@petermbenglish\u2069 changed his mind about the one v two vaccine dose controversy. He blogs why here. https://t.co/W8I5cm7LAk
— Trisha Greenhalgh \U0001f637 #RejoinEU (@trishgreenhalgh) January 2, 2021
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[Free CDMO Masterclass #18] https://t.co/208eQbYKEF
[Free Art of Investing] https://t.co/bHvUqnpiTE
[Paid IIC Dec 2020 on SeQuent] https://t.co/3iDO438Et9
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Twitter should be like that airport shuttle service, the moment you walk out (start following someone) - there should be a chauffeur (new stock idea) ready to drive you to your destination!
[Free CDMO Masterclass #18] https://t.co/208eQbYKEF
[Free Art of Investing] https://t.co/bHvUqnpiTE
[Paid IIC Dec 2020 on SeQuent] https://t.co/3iDO438Et9
[Charity fund raise on Unseen Trends in Biotechnology] https://t.co/eNi1x1qwhH
[Q&A on APIs]