@Daoyu15 @franciscodeasis @spectropan @ResearchGate @TheSeeker268 STRANGE TO SEE THIS IN Wuhan Hu-1
Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1
Clostridium_difficile
Bat coronavirus BM48-31/BGR/2008
Human coronavirus 229E

@franciscodeasis @spectropan @ResearchGate @TheSeeker268 A Bulgarian Bat Virus mentioned in Lam et al:
Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China
https://t.co/XRV8YfQ62F

@franciscodeasis @spectropan @ResearchGate @TheSeeker268 Bat coronavirus BM48-31/BGR/2008

Drosten

https://t.co/TB7hfDmsD0
and
https://t.co/JiVyAkL3H5

@franciscodeasis @spectropan @ResearchGate @TheSeeker268 Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences.
https://t.co/apTzRc4RnK

@franciscodeasis @spectropan @ResearchGate @TheSeeker268 Complete Genome Sequence of a SARS - Related Coronavirus from Kenyan Bats
Tao and Tong
https://t.co/pz17H1Abvm

Compilation Thread on ORF8 ORF8 or Fate?
1. ZLS (2018):
"Considering the variability of orf8 in bats, civets and humans, investigating the function of orf8 is a priority, particularly the contribution of these different variants to viral pathogenesis."

2. ORF8 or Fate?
"In addition to receptor binding, proteolytic cleavage of S & potentially other mutations that affect virion & trimer stability may be important for virus transmissibility in different hosts, & these factors need to be studied

3. ORF8 or Fate?
Overwhelmingly these viruses had mutations or
29 deletions in ORF8 - associated with reduced replicative fitness of the virus.. may be associated with host adaptation
via @CarltheChippy
382-nt deletion during early evolution of

4. ORF8 or Fate?
@franciscodeasis reviewed the list of read filenames according to dates and labels:
- Sat 2017-06-03 (7896)
- Sat 2017-06-17 to Tue 2017-06-20 (7896 and ORF8)
- Thu 2018-09-27 to Sun 2018-09-30 (RaTG13)
- Mon 2018-10-08 to Sun 2018-10-14 (no label and TSS)

5. ORF8 or Fate?
What is ORF8? This is Orf8!
https://t.co/21ugtiinhL