Open Letter: “Is this Nate?”
It’s sizzling in my chest, so here it is. I don’t want to hurt the poor guy who called me—probably forced to call me—but it needs to be said. Yesterday, at about 11:00 at night, I got a call from a representative of the Governor’s office.

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I don't think people understand the vital difference between a well-rehearsed (and physical) team vs a collection of individuals with no real understanding - new players, makeshift centre-backs, other players out of position. Make do an mend when missing a ton of quality = v.hard
Add fatigue,with less option to rotate, and big effort in 3 away games in previous 9 days. Team lacks height and heft without VvD, Matip, Fabinho, Gomez. Team lacks pace and goals without Jota, Mané. Lacks pace at back without VvD and Gomez. No senior keeper undermines confidence
Team has been disrupted constantly this ssn. Rarely below 6 injuries, often = 10. Thiago a real bonus after months out, but the proper team is not around him. Even Gini looked knackered yesterday. 5th/6th-choice strikers and centre-backs will always be a big drop from 1st choices
Last night was a bit grim, and Brighton were excellent. But it was a strong XI for them, in terms of usual players and in terms of physicality. LFC full of skilful slower little guys right now - lacking the skilful bodyguards and pace. Kabak should help, but he's young and new
You can read Mentality Monsters or Perched for how much I talk about the unity of a team, the practiced understanding from years of intense training together, knowing each others runs and movements. Right now it's a team of semi-strangers and stand-ins.
Definitely agree BUT, we should still be beating Burnley and Brighton at home.
— PaulShilly \U0001f339\U0001f339 (@shillcock_paul) February 4, 2021
For me, that is in part, a tactical problem.
Add fatigue,with less option to rotate, and big effort in 3 away games in previous 9 days. Team lacks height and heft without VvD, Matip, Fabinho, Gomez. Team lacks pace and goals without Jota, Mané. Lacks pace at back without VvD and Gomez. No senior keeper undermines confidence
Team has been disrupted constantly this ssn. Rarely below 6 injuries, often = 10. Thiago a real bonus after months out, but the proper team is not around him. Even Gini looked knackered yesterday. 5th/6th-choice strikers and centre-backs will always be a big drop from 1st choices
Last night was a bit grim, and Brighton were excellent. But it was a strong XI for them, in terms of usual players and in terms of physicality. LFC full of skilful slower little guys right now - lacking the skilful bodyguards and pace. Kabak should help, but he's young and new
You can read Mentality Monsters or Perched for how much I talk about the unity of a team, the practiced understanding from years of intense training together, knowing each others runs and movements. Right now it's a team of semi-strangers and stand-ins.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs

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A thread 🧵
1) Learn Anything - Search tools for knowledge discovery that helps you understand any topic through the most efficient
2) Grad Speeches - Discover the best commencement speeches.
This website is made by me
3) What does the Internet Think - Find out what the internet thinks about anything
4) https://t.co/vuhT6jVItx - Send notes that will self-destruct after being read.