Demystifying Ghazwa-e-Hind. A #thread.

A recent video of Shoaid Akhter surfaced in social media creating a lot of controversy where the #Pakistani Cricketer can be seen suggesting invasion of India by using the term Ghazwa-e-Hind.
Radicalization of sportsmen seen off late
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1/ The “I Have a Dream" speech is one of the most extraordinary speeches in American history. You should read it again. First, a few thoughts about the common American heritage Dr. King relied upon in calling Americans to rededicate themselves to the unfinished work of freedom.

2/ Dr. King delivered his speech in what he called the “hallowed spot” of the Lincoln memorial. More than a picturesque backdrop, King relied on America’s reverence for Lincoln and the common celebration of Lincoln’s words and acts, especially the Emancipation Proclamation.

3/ “Five score years ago…” King echoes the words of the Gettysburg Address. Like Lincoln, King invokes the Declaration of Independence and the fundamental principles of American freedom, “life, liberty and the pursuit of happiness.” Every person in that crowd knew these words.

4/ The Declaration, Constitution and Emancipation Proclamation declared and established the fundamental American principles of freedom that all Americans knew and believed in. But these principles and promises remained unfulfilled for black Americans.

5/ Lincoln’s audience knew the history of slavery and many had suffered personal loss in the ongoing war. Dr. King’s audience knew the history of violent racism, segregation, and unequal economic opportunity. The Proclamation freed the slaves, “but the Negro still is not free.”

1/14 How do e-cigarettes (ECs) affect cigarette smoking among youth? My new paper with @FloeFoxon simulates each scenario and finds out which one best matches actual trends... https://t.co/dBB7kcnTls @jgitchell @mikepesko @SwitchFinder @jkelovuori @TobPolicy @Clive_Bates

2/14 First, let's talk about why this question is so difficult to answer: COUNTERFACTUALS. We can't know the alternate-reality answers, like which smokers would have never started in a world without ECs, and which nonsmokers would now be smoking without ECs as an option.

3/14 So, the best we can do is use fancy/sophisticated methodologies to estimate what would have happened to youth smoking rates in the absence of ECs. In our case, simulation modeling

4/14 First, we look at the declining smoking trends *that were already happening* before ECs came (~2010), and project them into the present. This is our BASE-CASE SCENARIO about what smoking trends would be if ECs were never invented. Actual trends were LOWER than this base-case

5/14 Side note about terminology: We use the term “catalyst” instead of “gateway,” because “catalyst” is more precise about the claim we are modeling (that ECs are used first, and then causally lead to smoking). Whereas "gateway" can include other mechanisms like renormalization.

Remember: Just because an idea is old doesn't mean it's good.

Knowing whether old ideas are more likely to be good requires understanding whether conditions have changed in important ways.

Horse archery was an amazing method of warfare for over a thousand years...then people invented guns, and suddenly this great idea that had stood the test of time became obsolete.

Then again, when underlying conditions don't change much, tried-and-true approaches are probably better.

"Learning the lessons of history" usually just means assuming ergodicity and stationarity in an informal time-series model...

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@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

Thread

"Main jab mar jaun to meri alag se pehchan likh dena,mere lahu se meri peshani pr Hindustan likh dena(After I die,write my identity differently,with blood,write India on my forehead)”- msg on wall in Brijpuri. It's faded.

A year on,we revisit where #DelhiRiots broke out.

Feb 2020 Vs Feb 2021
While the hustle and bustle of the area has returned in severely hit Shiv Vihar, some cracks in the walls, a black smoke patch on the door, a few burnt utensils and a pile of photographs remind the victims of the days and nights they lived in “terror”.

Khushnaz’s daughter Alfiza was six days old on February 25 when the riots broke out near her house. She recalled pressing her palm against the infant’s mouth to prevent her voice from being heard as she cried.

Shawra Begum’s single-storey residence near Medina Masjid has still not been repaired. Looking at the broken and burnt taps of her washroom, Shawra said, “That time reminds me of death.”

Sitting inside his house near Auliya Masjid, Nizamuddin had tears in his eyes thinking about the time. Over 5,000 men were walking and running amok on the streets destroying everything and everyone, he said.