So where are we at with this virus people?

The calamoid palms 🌴 have over 500 species spread across the world, but their higher-level relationships were a bit of a mystery. Until now.

Out today in #MolecularPhylogeneticsAndEvolution:

A robust phylogenomic framework for the calamoid palms https://t.co/JiCbSUlheH

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First some background info, so that you know what we are talking about:

Calamoid palms look a bit like snakes 🐍 (don't they!?!), because their fruits are covered in overlapping scales. And with their often fierce spines, they are equally fearsome. 😱

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They are classified into 17 genera, 10 subtribes and 3 tribes. They have an amazing variety of growth forms, from stemless to climbing to tree habit. 🌱🌴

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But as I said, their relationships have been a bit of a mystery. Here's the varying relationships previous studies found over the last 20 years.

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We tackled this mystery with a phylogenomic approach: we sampled almost a thousand genes (a hundred times more than previous studies!) of 75 species representing all calamoid tribes, subtribes and genera.

The resulting data matrix is pretty massive...

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$Asbj\xf8rn St\xf8ylen$

Asbjørn Støylen
@strain_rate

1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.

The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.

2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.

3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.

4/ The stretching of the septum builds up an elastic tension in the septum, which is released as recoil, when tension declines in the lateral wall, showing a post systolic shortening in the septum which is due to elasticity.

John Parkinson
@profparkinson

Colleagues, we need to talk about the damage that endless zooming can do. Every day I see new opportunities to join in this or that online discussion or conference, and each invitation is becoming a burden 1/... #AcademicTwitter #AcademicChatter

For many of us, online conferencing is the main form of contact we have with others. But it's a stripped down form of contact which demands a particular focus and concentration. Colleagues tell me every day that it's more intense, and thus tiring, than IRL interaction 2/...

Communication is attenuated because many of the usual social and symbolic cues that tell us where we are, what our role is, how to interact and respond, are missing. This is especially awful if our interlocutors have their cameras switched off and we're talking into a void 3/...

But we also lose the rest and reset time between events. Instead of those precious minutes on a train to read, or a brisk walk between venues, even just a chat around the coffee pot, we are increasingly leaving one meeting to log on to another 4/...

We do so with no other backdrop than our own four walls, in one chair, glued to a screen, unable to reach out. Our symbolic and social worlds have shrunk. @PostEurope told me it's a form of torture, but that's literally true: a stress position we maintain for days 5/...

Bert Hubert
@PowerDNS_Bert

Recently I learned something about DNA that blew my mind, and in this thread, I'll attempt to blow your mind as well. Behold: Chargaff's 2nd Parity Rule for DNA N-Grams.
If you are into cryptography or reverse engineering, you should love this.
Thread:

DNA consists of four different 'bases', A, C, G and T. These bases have specific meaning within our biology. Specifically, within the 'coding part' of a gene, a triplet of bases encodes for an amino acid

Most DNA is stored redundantly, in two connected strands. Wherever there is an A on one strand, you'll find a T on the other one. And similarly for C and G:

T G T C A G T
A C A G T C A

(note how the other strand is upside down - this matters!)

If you take all the DNA of an organism (both strands), you will find equal numbers of A's and T's, as well as equal numbers of C's and G's. This is true by definition.
This is called Chargaff's 1st parity rule.
https://t.co/jD4cMt0PJ0

Strangely enough, this rule also holds per strand! So even if you take away the redundancy, there are 99% equal numbers of A/T and C/G * on each strand *. And we don't really know why.
This is called Chargaff's 2nd parity rule.

Trespassers William
@Mammoth_Spotter

Read this thread from @lilithsaintcrow. I really mean it. Just read it. Because if what she is saying is true (and I happen to think it is) it explains *so much*

An example using the Flat Earthers: A thread of many parts:

Let me explain something to those of you who didn't grow up around violently abusive white supremacists.

*They absolutely do not believe their own bullshit*, but it's useful for them to pretend they do.
— Lili Saintcrow (@lilithsaintcrow) January 7, 2021

I'm firmly convinced that the flat Earth thing was started by some adolescent trolls with nothing more productive to do. They didn't believe it, but they thought it was entertaining to keep pretending that they did.

You can't engage with them, because they *are playing a game*. They think it's fun to see if they can get anybody to engage with something completely stupid as though it's true.

If you challenge them, the rules of the game state that they have to argue as hard and a spuriously as they like, but *never* to admit that the Earth is not in fact flat. I suppose you have to make up your own entertainment on 4chan or whatever hole this was conceived in.

It's annoying as hell, but I suppose it doesn't do much harm.. except to folks like this:

So where are we at with this virus people?

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