BC SCIENCE
Saved by @CodyyyGardner

Check out this special feature of #ProcB edited by @bkoskella @gut_health and me. Thanks to the authors for their excellent article contributions - and all articles are #freetoread. Hopefully there is something of interest for all #microbiome researchers here @RSocPublishing

 Application of ecological and evolutionary theory to microbiome community dynamics across systems | Proceedings of the Royal Society B: Biological Sciences https://t.co/LzzUDDE7Qg @jamesemcdonald
@gut_health
@bkoskella
@RSocPublishing
Transmission efficiency drives host–microbe associations | Proceedings of the Royal Society B: Biological Sciences https://t.co/bBdGS1XdTo
@PhilipLeftwich
Matthew P. Edgington
and Tracey Chapman
Host–microbiota–insect interactions drive emergent virulence in a complex tree disease | Proceedings of the Royal Society B: Biological Sciences https://t.co/RpwpxgHgY4
@clydeandforth1
Martin Broberg
Sandra Denman
@jamesemcdonald
A game theory model for gut bacterial nutrient utilization strategies during human infancy | Proceedings of the Royal Society B: Biological Sciences https://t.co/o3kIzv0ZbR
Inga Leena Angell
Knut Rudi
Disruption of cross-feeding interactions by invading taxa can cause invasional meltdown in microbial communities | Proceedings of the Royal Society B: Biological Sciences https://t.co/DXxkyswaBn
@CristinaHerren
The role of the gut microbiome in sustainable teleost aquaculture | Proceedings of the Royal Society B: Biological Sciences https://t.co/9zNtdIj4hp
@WillPerryMEFGL
Elle Lindsay, Christopher James Payne, Christopher Brodie and Raminta Kazlauskaite
A bird's-eye view of phylosymbiosis: weak signatures of phylosymbiosis among all 15 species of cranes | Proceedings of the Royal Society B: Biological Sciences https://t.co/k4dfmPTXkS
@BrianTrevelline Jahree Sosa, Barry K. Hartup and
@KevinDKohl
An introduction to phylosymbiosis | Proceedings of the Royal Society B: Biological Sciences https://t.co/Tqgf5HEur3
Shen Jean Lim and @Symbionticism
Microbial and volatile profiling of soils suppressive to Fusarium culmorum of wheat | Proceedings of the Royal Society B: Biological Sciences https://t.co/wsqe2KT5c0
Adam Ossowicki, Vittorio Tracanna, Marloes Petrus, @GillesvanWezel Jos Raaijmakers, Marnix Medema @PaolinaGarbeva
Into the wild: microbiome transplant studies need broader ecological reality | Proceedings of the Royal Society B: Biological Sciences https://t.co/JGRDh76HWt
@cgreysongaito, Timothy Bartley, Karl Cottenie, Will Jarvis, @Newman_lab and @M_Stothart
Microbial evolution and ecological opportunity in the gut environment | Proceedings of the Royal Society B: Biological Sciences https://t.co/m1FJRZcgmJ
@PaulineDScanlan
It's what's on the inside that counts: stress physiology and the bacterial microbiome of a wild urban mammal | Proceedings of the Royal Society B: Biological Sciences https://t.co/0flhlcEii0
@M_Stothart
Rupert Palme
@Newman_lab
Sorry if I missed any authors' Twitter handle - please tag them in!
Big thanks also to the manuscript reviewers for their insightful and helpful comments, and @RSocPublishing for their excellent support. Please consider #ProcB or the other @RSocPublishing journals for your next #microbiome #microbiology submission!

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KenOliveLab
KenOliveLab
@KenOliveLab
Extremely excited today to reveal the first of two great works (magnus opera?), just posted on bioarxiv, applying regulatory network analysis techniques to PDAC expression data to dissect the underlying biology of the disease. Tweetorial time! 1/

Eight years ago I launched an enduring collaboration with Andrea Califano @ColumbiaCancer to apply his regulatory network analysis techniques to #pancreaticcancer. So many amazing scientists have contributed to this work: @paslaise @hc_maurer @AlvaroCurielGa1 @ElyadaEla 2/

What is “regulatory network analysis”? At it's heart, it's a way of extracting more useful information from expression profiles. A fundamental flaw of differential gene expression (DGE) analysis is the assumption that each gene is independent. Biologist KNOW this is not true! 3/


DGE treats all ~25K detectable genes as SEPARATE variables, performs 25K T-tests, and then slaps on a multiple hypothesis correction to make the statisticians less dyspeptic. There is no consideration of the relationships between genes! 4/

Yet we KNOW genes are co-regulated in SETS by transcription factors and other REGULATORY FACTORS. Biologist: “p21 is a target of p53”. DGE: “Shhhh”. These relationships are completely ignored by expression analysis. THIS IS A TRAVESTY! 5/
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Shrey Srivastava
Shrey Srivastava
@BlogShrey
#DDDD $LBPS $LOAC

A thread on the potential near term catalysts behind why I have increased my position in 4d Pharma @4dpharmaplc (LON: #DDDD):


1) NASDAQ listing. This is the most obvious.

The idea behind this is that the huge pool of capital and institutional interest in the NASDAQ will enable a higher per-share valuation for #DDDD than was achievable in the UK.

Comparators to @4dpharmaplc #DDDD (market capitalisation £150m) on the NASDAQ and their market capitalisation:

Seres Therapeutics: $2.33bn = £1.72bn (has had a successful phase 3 C. difficile trial); from my previous research (below) the chance of #DDDD achieving this at least once is at least


Kaleido Biosciences: $347m = £256m. 4 products under consideration, compared to #DDDD's potential 16. When you view @4dpharmaplc's 1000+ patents and AI-driven MicroRx platform (not to mention their end-to-end manufacturing capability), 4d's undervaluation is clear.
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Jambavan
Jambavan
@SirJambavan
https://t.co/odzm9VTdwZ

Thread for today. /0

It is fashionable for people to create sympathy to the unseen / unknown organisms. The poor things that can't stand up and fight for their own existence.

It makes for a brilliant narrative. It melts your hearts. And you get to play saviour of the oppressed by outraging. /1

But, for most part, such things are also false.

Amazon are the lungs of the world. Never mind that most of the world's oxygen production happens in open oceans. But these are harmless ones. Of course, we all love to maintain forests.

However, some things are sheer scare mongering.

For instance - take this: coral reefs will be permanently gone if mean / median temperatures raise by 1°C ..

But, really - how? Then you get a lecture on how CO2 will affect calcification.

Dig a bit deeper from another angle+

+ and you find that the earth was much much warmer during the age of Dinosaurs. So much so, that we had cold blooded lizards growing to sizes of buildings. Surely, there must have been tons of CO2 then!

And the ocean temps were quite high too.
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10-K Diver
10-K Diver
@10kdiver
1/

Get a cup of coffee.

In this thread, I'll help you understand the basics of Binomial Thinking.

The future is always uncertain. There are many different ways it can unfold -- some more likely than others. Binomial thinking helps us embrace this view.


2/

The S&P 500 index is at ~3768 today.

Suppose we want to predict where it will be 10 years from now.

Historically, we know that this index has returned ~10% per year.

If we simply extrapolate this, we get an estimate of ~9773 for the index 10 years from now:


3/

What we just did is called a "point estimate" -- a prediction about the future that's a single number (9773).

But of course, we know the future is uncertain. It's impossible to predict it so precisely.

So, there's a sense of *false precision* in point estimates like this.

4/

To emphasize the uncertainty inherent in such predictions, a better approach is to predict a *range* of values rather than a single number.

For example, we may say the index will return somewhere in the *range* of 8% to 12% (instead of a fixed 10%) per year.

5/

10 years from now, this implies an index value in the *range* [8135, 11703]:
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James Hay
James Hay
@jameshay218
Ct values can be used to estimate epidemic dynamics UPDATE! Ct values are expected to change depending on whether the epidemic is growing or declining, and we harness this to estimate the epidemic trajectory. Lots of cool new analyses and methods!

Highlights:
- Cts from symptom-based surveillance change over time, but the effect is weaker
- Methods to infer incidence using single cross-sections of Cts
- Unbiased by changing testing coverage
- Gaussian process (wiggly line) model for incidence tracking using Ct values
2/12

This work is *JOINTLY led* with @LeekShaffer and PI’d by @michaelmina_lab. Thank you also to the ever insightful @mlipsitch and to coauthors @SanjatKanjilal @gabriel_stacey and @nialljlennon. 3/12

Premise: times since infection depend on the epidemic trajectory. Distributions of randomly sampled viral loads proxy times since infection. With calibration, Ct values can estimate growth rate. We focus on qPCR in SARS-CoV-2, but the principle applies to any outbreak. 4/12

Result 1: viral loads are shifted higher (Cts lower) during epidemic growth and lower (Cts higher) during decline when individuals are sampled *based on the onset of symptoms*. We simulated linelist data under symptom-based surveillance and looked at TSI and Cts over time. 5/12
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In collaboration with @niki_poojary


Importance of Trading only BO or BD stocks by @Mitesh_Engr Sir: 👇

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When and Why to Pyramid? By @Mitesh_Engr Sir

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Have covered:
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2. Workbook
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4. Diff category of days
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1. Keeps following volatility super closely.

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Whichever gives highest profit he trades in.


2. Theta falls when market moves.
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Anu Satheesh
@AnuSatheesh5
Alathiyur Hanuman Temple
Malappuram, Kerala 🚩
#keralatemples

One of the Powerful Anjaneya Temples in Kerala. Hanuman temple is adjacent to Shri Ramar Sannidhi. Here Hanuman's head is tilted towards the left to hear Shri Rama's words. Shri Rama is entrusting Hanuman👇


Task of locating Mata Sita in Lanka.

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Hanuman stands leaning a little towards the left, showing how he hear Shri Rama's words and also assuring him Your Wish is my Command.
The Vigraham of Hanuman gives us the Strength, Confidence and Bhakthi.
There is a place marked here to show Hanuman’s leap to Lanka over sea.


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Alathiyur Hanumane
Pedi Swampnam kanarudhe
Pedi Swapnam Kandalo
Val Kondu Thattiyunarthename
🙏🕉🙏
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SRI BANASHANKARI AMMAN, BANGALORE
#bharatmandir

Located in Southern Bangalore, this is one of the most popular places of worship in Bangalore City.
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Somanna Shetty, a great devotee of Devi, brought this murti from Badami’s Banshankari Amma Kshetram.
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However, upon their insistence, he conducted the puja. When he returned with prasadam, the ladies vanished. This made the people believe that they were none other than the Devi herself. Since then, the people perform poojas here during the Rahukaal.
@GunduHuDuGa


People use lemons as a diya. Lemons are cut from the centre and their pulps are removed, for pouring oil in them.
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#24hrstartup recap and analysis

What a weekend celebrating makers looks like.

A thread

👇Read on

Let's start with a crazy view of what @ProductHunt looked like on Sunday

Download image and upload

A top 7 with:
https://t.co/6gBjO6jXtB @Booligoosh
https://t.co/fwfKbQha57 @stephsmithio
https://t.co/LsSRNV9Jrf @anthilemoon
https://t.co/Fts7T8Un5M @J_Tabansi
Spotify Ctrl @shahroozme
https://t.co/37EoJAXEeG @kossnocorp
https://t.co/fMawYGlnro

If you want some top picks, see @deadcoder0904's thread,

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