unimpressive. Many plants & amphibians, for instance, have larger genomes. We're not so much the genomic crown of creation as a cul-de-sac of creation.
I've been reading the wonderful book "Cell Biology by the Numbers" (https://t.co/rLzAiv32Dq ). Here's a thread of striking things I learned from the book (or related reading)
unimpressive. Many plants & amphibians, for instance, have larger genomes. We're not so much the genomic crown of creation as a cul-de-sac of creation.
Amazingly rapid mixing!
If you wanted a really viral tweet, you could just put the porcine circovirus genome in your tweet!
(It's possible I need to get out more. I blame 2020!)
A Hewlett-Packard researcher once told me they think about controlling printer fluid with femtoliter precision.
It's incredible that all these things are called "cells". If I met a person 100,000 times larger than me, I'd think a new category was called for!
More from Culture
A thread of very good, wonderful, truly Super Bowls.
Translucent agate bowl with ornamental grooves and coffee-and-cream marbling. Found near Qift in southern Egypt. 300 - 1,000 BC. 📷 Getty Museum https://t.co/W1HfQZIG2V
Technicolor dreambowl, found in a grave near Zadar on Croatia's Dalmatian Coast. Made by melding and winding thin bars of glass, each adulterated with different minerals to get different colors. 1st century AD. 📷 Zadar Museum of Ancient Glass https://t.co/H9VfNrXKQK
100,000-year-old abalone shells used to mix red ocher, marrow, charcoal, and water into a colorful paste. Possibly the oldest artist's palettes ever discovered. Blombos Cave, South Africa. 📷https://t.co/0fMeYlOsXG
Reed basket bowl with shell and feather ornaments. Possibly from the Southern Pomo or Lake Miwok cultures. Found in Santa Barbara, CA, circa 1770. 📷 British Museum https://t.co/F4Ix0mXAu6
Wooden bowl with concentric circles and rounded rim, most likely made of umbrella thorn acacia (Vachellia/Acacia tortilis). Qumran. 1st Century BCE. 📷 https://t.co/XZCw67Ho03
Translucent agate bowl with ornamental grooves and coffee-and-cream marbling. Found near Qift in southern Egypt. 300 - 1,000 BC. 📷 Getty Museum https://t.co/W1HfQZIG2V
Technicolor dreambowl, found in a grave near Zadar on Croatia's Dalmatian Coast. Made by melding and winding thin bars of glass, each adulterated with different minerals to get different colors. 1st century AD. 📷 Zadar Museum of Ancient Glass https://t.co/H9VfNrXKQK
100,000-year-old abalone shells used to mix red ocher, marrow, charcoal, and water into a colorful paste. Possibly the oldest artist's palettes ever discovered. Blombos Cave, South Africa. 📷https://t.co/0fMeYlOsXG
Reed basket bowl with shell and feather ornaments. Possibly from the Southern Pomo or Lake Miwok cultures. Found in Santa Barbara, CA, circa 1770. 📷 British Museum https://t.co/F4Ix0mXAu6
Wooden bowl with concentric circles and rounded rim, most likely made of umbrella thorn acacia (Vachellia/Acacia tortilis). Qumran. 1st Century BCE. 📷 https://t.co/XZCw67Ho03
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs